Selective Microbial Metabolism Regulation Technology



Biofilms are everywhere. Microbial biofilms account for 80% of infections in humans, multi-drug resistance and agricultural waste (spoilage), resulting in over $550B USD in associated cost on an annual basis. Current approaches to limit adverse events and costs associated with unruly biofilms utilize a century-old theory. That the use of toxic chemicals or antibiotics to curtail the growth or kill unwanted microbes is the best approach. Long-term meta-analysis data are telling us that is not the case, as multi-drug resistance in bacteria is an ever-increasing problem around the globe and the use of toxic chemicals (e.g., triclosan) to limit microbial growth poses significant health risk to humans.

Scientific studies are also showing us that there are certain microbial species that are beneficial, and their absence in a human or animal, is linked to the development or severity of certain diseases (e.g., certain Clostridia and Lactobacillus spp. are linked to positive health outcomes); so there are certain microbes we wish to protect and/or enrich in a biofilm to promote health, well-being and longevity.

We have therefore developed a novel proprietary approach to combat the unwanted pesky microbes (or their bad behaviors and metabolic effectors) while leaving the beneficial microbes relatively untouched, and in a manner that does not utilize traditional ‘molecular sledgehammer’ approaches. Our SMMRT approach (Selective Microbial Metabolism Regulation Technology) has given rise to an initial pipeline of formulations that combat unwanted microbial effects.